Choosing the OS protocol: hCG helps modelling nature

天然提煉的尚好，老藥未必不如新藥，2020年6月22日的The IBSA Educational Program提供的Webinar，介紹由 #Meriofert 這個由孕婦尿液純化而來的hMG，雖然有點老王賣瓜，但仍能提供臨床醫師的用藥另類參考！
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Choosing the OS protocol: hCG helps modelling nature

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Speaker: Dominique de Ziegler, MD
Moderator: Pedro Barri, MD
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22nd June 6pm CEST
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#Agenda
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1. LH in the menstrual and OS cycles
2. LH effects: LH vs hCG
3. hMG Vs rFSH Pregnancy: Live birth and cumulative live birth rates, number of oocytes
4. Placental hCG and pituitary hCG: More oocyte, less medication
5. Patients profiles suitable for treatment with Meriofert
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●hCG increases serum and intrafollicular androgens
●hMG induces more oestrogens and less progesterone production compared to recFSH
●hMG results in significantly higher live birth rates than rFSH
●Meriofert is an highly purified hMG preparation containing 75 IU of follicle stimulating hormone (FSH) activity and 75 IU of LH activity.
●The LH activity is given prevalently by hCG from urine of pregnant women.
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#Conclusions
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●The suppression of LH levels in GnRH analogue cycles may be substantial and of clinical importance.
●hCG driven LH activity modulates folliculogenesis & steroidogenesis towards a more homogenous follicular cohort and a more androgenic follicular milleau.
●hCG driven LH activity appears to have a beneficial effect on embryo quality.
●The effect of hCG driven LH activity is interpreted into a significant effect on clinical outcomes with higher live birth rates as compared with rFSH
●However studies using hCG driven LH activity from menopausal pituatiry hCG resulted in significant lower oocytes retrieved as compared with rFSH.
●The use of placental hCG appears to be substantially different, in terms of purity isoform acidity.
●This diffrerence is intrepreted in clinical outcomes with a comparable beneficial effect on oocyte/embryo quality with pituitary menopausal hCG , but with higher efficacy profile in terms of number of oocytes retrieved and cumulative LBR.
●Placental hCG allow us deliver the effect of hCG-driven LH activity without compromise in the number of oocytes retrieved.
●The number of oocytes retrieved is strictly associated with cumulative LBR
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重播網址：https://youtu.be/7fHGLR03OJ4
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臉書連結：https://is.gd/YVrnBq
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